Mac as a service tool platform (World & others)

Has anyone had any luck running World Tools on a Mac? I'm curious if you might run it in Parallels or VMWare, if it runs in either, better on one, and if there is any problem with port communication. Same question might apply towards a hyper-terminal type program. The main question relates to USB communication, dongles, and emulation on a DB9/USB adapter. I'm assuming VMWare will run it all day. Looking for info so I can help move that question forward.